DEFINITION
The liver is an organ about the size of a football that sits just under your rib cage on the right side of your abdomen. The liver is essential for digesting food and ridding your body of toxic substances.
Liver disease can be inherited (genetic) or caused by a variety of factors that damage the liver, such as viruses and alcohol use. Obesity is also associated with liver damage. Over time, damage to the liver results in scarring (cirrhosis), which can lead to liver failure, a life-threatening condition.
CAUSES
Liver disease has many causes.
Parasites and viruses can infect the liver, causing inflammation and that reduces liver function. The viruses that cause liver damage can be spread through blood or semen, contaminated food or water, or close contact with a person who is infected. The most common types of liver infection are hepatitis viruses, including:
- Hepatitis A
- Hepatitis B
- Hepatitis C
Immune system abnormality
Diseases in which your immune system attacks certain parts of your body (autoimmune) can affect your liver. Examples of autoimmune liver diseases include:
- Autoimmune hepatitis
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
An abnormal gene inherited from one or both of your parents can cause various substances to build up in your liver, resulting in liver damage. Genetic liver diseases include:
- Hemochromatosis
- Hyperoxaluria and oxalosis
- Wilson’s disease
Cancer and other growths
Examples include:
- Liver cancer
- Bile duct cancer
- Liver adenoma
Additional, common causes of liver disease include:
- Chronic alcohol abuse
- Fat accumulating in the liver (nonalcoholic fatty liver disease)
SYMPTOMS
Signs and symptoms of liver disease include:
- Skin and eyes that appear yellowish (jaundice)
- Abdominal pain and swelling
- Swelling in the legs and ankles
- Itchy skin
- Dark urine color
- Pale stool color, or bloody or tar-colored stool
- Chronic fatigue
- Nausea or vomiting
- Loss of appetite
- Tendency to bruise easily
Make an appointment with your doctor if you have any persistent signs or symptoms that worry you. Seek immediate medical attention if you have abdominal pain that is so severe that you can’t stay still.